Empirical Study on Anti-oxidative Effect of Grape Seed Extract

Objective To study the anti-oxidative effect of grape seed extract.Methods Fifty mice were randomly divided into five groups of normal control,model control and low,moderate,high dose groups.In normal control and model control groups,corn oil was given orally.In low,moderate,high dose groups,grape seed extract was given orally.After 30 days,the activities of GSH-Px,SOD in blood were measured.Then,all the groups except normal control group received one-time 5￣8Gy60C0 γ ray for the whole bodies.At the fourth day after radiation,all the mice were killed and the activities of GSH-Px,SOD in hepatic tissues were measured.The difference among all groups was compared.Results After 30 days,SOD activity in blood in moderate and high dose groups,and the activities of GSH-Px in blood and GSH-Px,SOD in hepatic tissues in high dose group were higher than that in model control group.The level of malonaldehyde(MDA) in hepatic tissues in all dose groups was lower than that in model control group.Conclusion Grape seed extract can inhibit the lipid peroxidation and have an anti-oxidative effect.