Anti-oxidative Effect of Different Dose of Grape Seed Extract in Human Body

Objective To study the anti-oxidative effect of different dose of grape seed extract soft capsule in human body.Methods Twenty-eight healthy volunteers aging from 60 to 65 were randomly divided into four groups: control group and low dose,middle dose,high dose group.Seven volunteers were in each group.The control group was given nothing.Each dose group was given grape seed extract soft capsule equivalent to 50 mg,100 mg or 150 mg of procyanidin forone month.The activities of SOD、GSH-Px and the level of MDA in serum were measured both prior to and after the experiment.Results After the experiment,the SOD activity in the high dose group was higher than before(P0.05);the GSH-Px activities in the middle and high dose groups were both higher than before(P0.05,P0.01,respectively) and that in the high dose group was higher than control group(P0.05);the levels of MDA in the middle and high dose groups were both lower than before(P0.05,P0.01,respectively) and were also lower than control group(P0.05,P0.01,respectively).Conclusion After orally taken grape seed extract soft capsule for one month,middle and high dose groups(100 mg,150 mg) can show significant anti-oxidative effect.