Expression of multdrug resistance markers in lung cancer tissues and peripheral blood

Objective To investigate the expression level and its clinical significance of multidrug resistance(MDR)markers(MRP mRNA and LRP mRNA)in lung cancer tissues and peripheral blood,and then to explore clinical sense of the result.Methods The expression of Lung cancer resistance protein(LRP),multidrug resistance protein(MRP) of MDR makers were detected in 47 cases of patient lung cancer tissues by reverse transcription and polymerase chain reaction(RT-PCR)technique.Results The positive expression rate of MRP mRNA in lung cancer tissues and peripheral blood was 74.5%(35/47)and 70.2%(33/47).A significant correlation was found between the two(r=0.686,P0.01);The expression of LRP mRNA was 82.9%(39/47)and 76.6%(36/47).It was significantly correlative between the two(r=0.368,P0.01).Therefore,there were significant relationships between MRP mRNA and LRP mRNA expression in lung cancer tissues(r=0.384,P0.01).Conclusion The mRNA levels of MRP and LRP expression in the peripheral blood of lung cancer patients is closely related,as a result,detecting it can reflect the tolerance between the chemotherapeutic drug and lung cancer tissues indirectly.