Clinical Studies on Low-dose Atorvastatin and Fenofibrate for the Treatment of Combined Hyperlipidemia

Objective To study the efficacy and safety of low-dose atorvastatin and fenofibrate for the treatment of combined hyperlipidemia.Methods 148 patients with combined hyperlipidemia were randomly divided into two groups.The observation group was treated with oral 100 mg of fenofibrate in the morning,with 10 mg of atorvastatin in the evening.The control group took 20 mg of atorvastatin every night.The treatment lasted 8 weeks.Changes in blood lipid levels and incidence of side effects were observed.Results TC,TG,LDL-C levels decreased significantly(P0.05),and HDL-C level was significantly higher in the observation group(P0.05).TC,LDL-C decreased significantly in the control group(P0.05).Compared with the control group,TG level was significantly lower(P0.05),and HDL-C level was significantly higher in the observation group(P0.05).The total effective rates of observation group and control group were 79.7% and 62.2% respectively(P0.01).The incidences of adverse reactions between the two groups had no significant differences.Conclusion Low-dose atorvastatin and fenofibrate for the treatment of combined hyperlipidemia is of good effect and low incidence of adverse reactions.