Treatment of combined hyperlipidemia in 122 elderly patients

Objective: To investigate the efficacy and safety of atorvastatin combining with fenofibrate on combined hyperlipidemia in patients aged over 70 years old.Methods: A total of 122 patients with combined hyperlipidemia were randomly divided into atorvastatin group(atorvastatin 10 mg/d,n=40) consecutive combining treatment group(atorvastatin 10 mg/d plus fenofibrate 20 mg/d,n=40) and alternative treatment group(alternate use of atorvastatin 10 mg/d and fenofibrate 20 mg/d,n=42).All 3 groups were treated for consecutive 3 weeks.Changes in the lipid level before and after the treatment,adverse effects were observed and compared.Results: In the combining treatment groups TG was significantly lowered and HDL-C increased compared with that in the atorvastatin group(P0.05),incidence of side effects in the alternative treatment group was 7.1%,significant lower than that of the consecutive combining treatment group(17.5%)(P0.05).Conclusions: With great safety and tolerance,alternative combining use of atorvastatin and fenofibrate is effective on combined hyperlipidemia patients aged over 75 years old.