Comparison of Combined Artificial Kidney to Maintain Quality of Life of Patients with Hemdialysis

Objective Comparison of hemodialysis( HD),hemodialysis combined with hemoperfusion( HP + HD),hemoperfusion and hemodiafiltration( HP + HDF) in 3 different ways of blood purification therapy for end-stage chronic complications in patients with end stage renal failure curative effect. Methods Randomized controlled trial using a choice of 180 uremic patients,before treatment,treatment for 3 groups of same,and then randomly divided into HD,HP + HD,HP + HDF 3 groups,each of 30 cases,treated for 6months. Observation of patients and treatment on nutritional status and complications in 6 months after the occurrence rate and related indexes of blood testing: iPTH,beta 2 microglobulin( β2-MG),leptin,CRP,ALB,calcium phosphorus product,blood routine to evaluate the safety and efficacy of 3 different treatment methods. Results The detection of target iPTH,beta 2 microglobulin( β2-MG),leptin,CRP,ALB between the control group and the experimental group had statistical significance,iPTH,CRP experimental group 1 and experimental group 2 showed no significant difference,leptin and β2-MG 2 group was better than the comparison experiment of removal experiment group 1,there was significant difference,no significant difference in blood routine data of 3 groups,severe adverse reaction did not occur during the experiment. Conclusion HP + HD and HP + HDF can alleviate the chronic complications in patients with end stage renal failure,the HDF + HP is more effective for removing toxin molecules.