2012•国际移植与血液净化杂志Requires access
The clinical observation of different blood purification treatment to refractory hypertension in end stage renal disease
Xin Cheng, Huang Ren-fa, Shen-chang Lai, Xiaolu Ma, Xiaoyun Wu
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Abstract
Objective To investigate the treatment effect of various blood purification methods in combination therapy in hemodialysis patients with refractory hypertension.Methods 60 patients with end stage renal disease refractory hypertension were randomly divided into 4 groups:control group,the hemodialysis group (HD),treatment group were divided into 3 groups:combined Hemodialysis hemodiafiltration group (HD + HDF),blood dialysis on blood perfusion group (HD + HP),blood dialysis and hemodiafiltration and then combined blood perfusion group(HD + HP + HP),Observe before treatment and after 8 weeks of treatment blood pressure and rennin-angiotensin (RA),angiotensin (Ang Ⅱ),Intact parathyroid hormone (iPTH) level.Results Before treatment,the observation indexes were no significant differences control group and treatment group,before and after treatment showed significant change both in the observation indexes,blood pressure and RA,AngⅡ,iPTH levels were significantly decreased (P ＜ 0.05).the three treatment groups compared with the control group blood pressure and Ang Ⅱ,iPTH levels were significantly decreased (P＜0.05),in the treatment group HD+ HDF+ Hp group and HD + HP group,HD + HDF group after treatment compared,blood pressure and RA,Ang Ⅱ,iPTH levels were significantly decreased (P ＜ 0.05).Conclusions Based on the maintenance of the treatment of hemodialysis combined hemodiafiltration and blood perfusion can effectively control refractory end stage renal disease hypertension.
Key words:
Hemodialysis; Hemodiafiltration; Blood perfusion; End stage renal disease; Refractory hypertension