Effect of hemodialysis combined with hemoperfusion on inflammation and nutrition status in maintenance hemodialysis patients

Objective To study the effect of hemodialysis (HD) combined with hemoperfusion (HP) on microinflammation and nutrition status in maintenance hemodialysis patients. Methods We collected 40 end-stage renal disease (ESRD) patients on hemodialysis,and randomly divided them into two groups:hemoperfusion combined with hemodialysis group (n=20,HP+HD group) and simple hemodialysis group (n=20,HD group). Before and after the treatment for 3 months,hemoglobin (Hb),and serum albumin (Alb),transferrin (TRF) and C-reactive protein (CRP) were measured on a biochemistry analyzer,and plasma leptin and tumor necrosis factor-a (TNF-a) were determined by radioimmunoassay. Results No significant differences in CRP,leptin,TNF-a,Hb,Alb and TRF were found between the 2 groups before treatment (P0.05). However,CRP,leptin and TNF-a significantly decreased after the treatment in HD+HP group (P0.05) but not in HD group. Hb and Alb significantly increased after the treatment in the 2 groups (P0.05). TRF increased after treatment only in HD+HP group (P0.01). After the treatment,Hb,Alb and TRF were higher in HD+HP group than in HD group (P0.05),and CRP,leptin and TNF-a were lower in HD+HP group than in HD group (P0.01). Conclusion HD combined with HP is an effective method to remove increased inflammation factors and to improve anemia and nutrition status,and is therefore beneficial to their living quality and life span.