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2019•Investigación ClínicaRequires access

Comparative Analysis of the Effects of Different Blood Purification Methods on Renal Anemia in Patients with End-Stage Renal Disease

Ya-Yin Tan

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Abstract

In order to explore the effect of different blood purification methods on renal anemia in patients with end-stagerenal disease (ESRD), 120 ESRD patients who underwent maintenance hemodialysis (MHD) treatment atdesignated hospitals by this research from June 2013 to June 2018 were selected as study subjects, and weredivided into three groups according to the random number table method: routine hemodialysis (HD) group,hemodiafiltration (HDF) group and hemoperfusion tandem hemodialysis (HP+HD) group with 40 cases in eachgroup. The patients in HD group only underwent hemodialysis alone, the patients in HDF group underwenthemodialysis + hemodiafiltration, and the HP+HD patients underwent hemodialysis + hemoperfusion; thesubjects' hemoglobin (Hb), serum ferritin (SF), serum iron (SI), blood urea nitrogen (BUN), hematocrit (Hct),electrolytes and other biochemical indicators as well as four macromolecular toxins of high-sensitivityC-reactive protein (hs-CRP), intact parathyroid hormone (i-PTH), interleukin 6 (IL-6) and β2 microglobulin(β2-MG) were tested respectively to evaluate the improvement of renal anemia in ESRD patients with differentblood purification methods. The results showed that after 3 months of treatment, hs-CRP and i-PTH in HP+HDgroup were higher than those in HD group, β2-MG was higher than that of HD group and HDF group, andi-PTH in HDF group was higher than that of HD group (P 0.05) while there were statistically significant differences betweenthe HDH group and the HDF group (P<0.05) after 12 months of treatment. After 12 months of treatment, Hb,Hct and BUN levels in the HP+HD group and the HDF group were higher than those in the HD group, and theHb and Hct levels in the HP+HD group were higher than those in the HDF group (P<0.05). Through analysis, itis believed that different blood purification methods have different effects on the improvement of renal anemiain patients with end-stage renal disease and adding hemodiafiltration and hemoperfusion to routine hemodialysiscan reduce the accumulation of molecular toxins in the body and reduce the long-term dialysis complications.

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What this paper is about

In order to explore the effect of different blood purification methods on renal anemia in patients with end-stagerenal disease (ESRD), 120 ESRD patients who underwent maintenance hemodialysis (MHD) treatment atdesignated hospitals by this research from June 2013 to June 2018 were selected as study subjects, and weredivided into three groups according to the random number table method: routine hemodialysis (HD) group,hemodiafiltration (HDF) group and hemoperfusion tandem hemodialysis (HP+HD) group with 40 cases in eachgroup. The patients in HD group only underwent hemodialysis alone, the patients in HDF group underwenthemodialysis + hemodiafiltration, and the HP+HD patients underwent hemodialysis + hemoperfusion; thesubjects' hemoglobin (Hb), serum ferritin (SF), serum iron (SI), blood urea nitrogen (BUN), hematocrit (Hct),electrolytes and other biochemical indicators as well as four macromolecular toxins of high-sensitivityC-reactive protein (hs-CRP), intact parathyroid hormone (i-PTH), interleukin 6 (IL-6) and β2 microglobulin(β2-MG) were tested respectively to evaluate the improvement of renal anemia in ESRD patients with differentblood purification methods. The results showed that after 3 months of treatment, hs-CRP and i-PTH in HP+HDgroup were higher than those in HD group, β2-MG was higher than that of HD group and HDF group, andi-PTH in HDF group was higher than that of HD group (P 0.05) while there were statistically significant differences betweenthe HDH group and the HDF group (P<0.05) after 12 months of treatment. After 12 months of treatment, Hb,Hct and BUN levels in the HP+HD group and the HDF group were higher than those in the HD group, and theHb and Hct levels in the HP+HD group were higher than those in the HDF group (P<0.05). Through analysis, itis believed that different blood purification methods have different effects on the improvement of renal anemiain patients with end-stage renal disease and adding hemodiafiltration and hemoperfusion to routine hemodialysiscan reduce the accumulation of molecular toxins in the body and reduce the long-term dialysis complications.

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Available abstract

In order to explore the effect of different blood purification methods on renal anemia in patients with end-stagerenal disease (ESRD), 120 ESRD patients who underwent maintenance hemodialysis (MHD) treatment atdesignated hospitals by this research from June 2013 to June 2018 were selected as study subjects, and weredivided into three groups according to the random number table method: routine hemodialysis (HD) group,hemodiafiltration (HDF) group and hemoperfusion tandem hemodialysis (HP+HD) group with 40 cases in eachgroup. The patients in HD group only underwent hemodialysis alone, the patients in HDF group underwenthemodialysis + hemodiafiltration, and the HP+HD patients underwent hemodialysis + hemoperfusion; thesubjects' hemoglobin (Hb), serum ferritin (SF), serum iron (SI), blood urea nitrogen (BUN), hematocrit (Hct),electrolytes and other biochemical indicators as well as four macromolecular toxins of high-sensitivityC-reactive protein (hs-CRP), intact parathyroid hormone (i-PTH), interleukin 6 (IL-6) and β2 microglobulin(β2-MG) were tested respectively to evaluate the improvement of renal anemia in ESRD patients with differentblood purification methods. The results showed that after 3 months of treatment, hs-CRP and i-PTH in HP+HDgroup were higher than those in HD group, β2-MG was higher than that of HD group and HDF group, andi-PTH in HDF group was higher than that of HD group (P 0.05) while there were statistically significant differences betweenthe HDH group and the HDF group (P<0.05) after 12 months of treatment. After 12 months of treatment, Hb,Hct and BUN levels in the HP+HD group and the HDF group were higher than those in the HD group, and theHb and Hct levels in the HP+HD group were higher than those in the HDF group (P<0.05). Through analysis, itis believed that different blood purification methods have different effects on the improvement of renal anemiain patients with end-stage renal disease and adding hemodiafiltration and hemoperfusion to routine hemodialysiscan reduce the accumulation of molecular toxins in the body and reduce the long-term dialysis complications.

Key concepts: Hemodialysis, Medicine, Blood urea nitrogen, Hemoperfusion, Hemoglobin, Anemia, Creatinine, Hematocrit

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Comparative Analysis of the Effects of Different Blood Purification Methods on Renal Anemia in Patients with End-Stage Renal Disease — Research Paper | ScholarLens