Relationship between serum Iron、Ferritin and lipid peroxidation injury in patients with chronic hepatitis B.

Objective To investigate the relationship between serum iron(SI),serum ferritin(SF) and lipid peroxidation injury in patients with chronic hepatitis B.Methods 79 patients with chronic hepatitis B were enrolled in this study.SI was detected by chromatometry,SF by Radio-immunity,MDA by thiobarbituric acid method,and SOD by xanthineoxidase method.Results Compared to control group,the level of SI,FE and MDA in patients with chronic hepatitis B were higher significantly(P0.05-0.01).On the contrary,the level of SOD in patients with chronic hepatitis B was lower significantly(P0.01).In 79 patients with chronic hepatitis B,correlation analyses found that SI and FE were in positive correlation with MDA(r=0.493,P0.01,r=0.745,P0.01),and SI was in negative correlation with SOD(r=-0.27,P0.05).Conclusion The levels of SI and SF in patients with chronic hepatitis B are closely related to lipid peroxidation injury,and the overload of iron may enhance the hepatocytes damage induced by HBV.