Change in Plasma Concentration of Malondialdhyde in Patients with Acute Viral Hepatitis

Objective In order to investigate whether lipid peroxidation increases in acute viral hepatitis. Methods Plasma malondialdehyde (MDA) concentration was determined in 36 patients suffering from acute viral hepatitis and in 27 healthy subjects. Results Mean plasma MDA concentration was 0.822+0.533 nmol/L for the acute hepatitis A group (n=11), 1.836±0.515 nmol/L for the acute hepatitis B group (n=25), and 0.589±0.227nmol/L for the control group (n=27), respectively. Plasma MDA levels of patients with acute hepatitis B were found to be higher than those in the control group and the differences were significant (P0.001). Conclusions The increased MDA levels found in acute hepatitis B prove the increase in lipid peroxidation.