Sarcoidosis:clinical analysis of 67 cases

Objective To explore the clinical features and diagnosis of sarcoidosis.Methods Clinical materials of 67 consecutive patients with biopsy-proven sarcoidosis were retrospectively analyzed.Results There were more female patients than males and the ratio of males to females was 1∶2.0.The average age was 47.1 years.There were 5,26,33 and 3 cases in stage 0,Ⅰ,Ⅱ and Ⅲ respectively.The main symptoms of respiratory tract included cough(52.2%),chest distress(41.8%) and anhelation(38.8%).The main general symptoms included hypodynamia,emaciation and fever.Eighty-three per cent of the patients had high levels of serum angiotensin converting enzyme.The diagnosis was confirmed in 78.6% by the transbronchical mucosa biopsies and 72.7% by the transbronchial lung biopsies.The diagnosis was confirmed in 100% by lymph node biopsy through mediastinoscopy.Conclusion No specific clinical manifestation may occur in the cases of sarcoidosis.Pathological examination should be made for the prevention of missed diagnosis and misdiagnosis.