Clinical observation of TP and NP regimen in the treatment of advanced breast cancer

Objective:To observe the efficacy and toxicity of paclitaxel and cisplatin(TP regime) versus navelbine cisplatin (NP regime) in the treatment of advanced breast cancer. Methods: 60 cases with advanced breast cancer were randomly di- vided into TP programme(30 cases) and NP programme(30 cases). 60 cases were treated with vinorelbine(NVB 30 mg/m 2,on days 1,8) plus cisplatin(DDP 30 mg/m2 on days 1,2,3) or paclitaxel(75 mg/m2 on days 1,8,15) plus cisplatin (30 mg/m2 on day 1,2,3) every 4 weeks. Analysis were done by intention to treat. Results: For TP regiment: the total effective rate was 50%(15/30),TTP was 8.1 months,the median survival time was 16 months, and the rate of survival in one year was 56.7% (17/30).For NP regiment: the total effective rate of was 40.0%(12/30),TTP was 6.9 months,the median survival time was 15 months,and the rate of survival in one year was 43.3%(13/30).The main adverse drug reactions of two regiments were restraint of marrow and gastrointestinal reactions. Conclusion: Combination of NP and TP has good therapeutic effect for patients with anthracycline-resistant ABC. And the toxic reponses is tolerable. There is no significant difference between objective responses of two regimens.