Protective action empirical study of melatonin on small intestine mucosa barrier of obstructive jaundice rats

Objective It is to discuss the protective action of melatonin on small intestine mucosa barrier of obstructive jaundice rats.Methods 36 rats were randomly divided into sham operated group(SO),obstructive jaundice group(OJ) and melatonin treatment group(MT).The levels of plasma endotoxin,TNF-α and IL-6,ICAM-1 expression and small intestine tissue morphological change were observed.The intestinal villus height and mucosal thickness were measured.Results Compared with SO group,the levels of plasma endotoxin,TNF-α and IL-6 in OJ group obviously heightened(P0.01),ICAM-1 expression in OJ group obviously strengthened(P0.01) and the intestinal villus height and mucosal thickness in OJ group obviously lowered(P0.01).Compared with OJ group,the levels of plasma endotoxin,TNF-α and IL-6 in MT group lowered(P0.01),ICAM-1 expression in MT group obviously weakened(P0.01),the intestinal villus height and mucosal thickness in MT group heightened(P0.01) and the damage of intestinal tissue structure lightened(P0.01).Conclusion Melatonin can protect small intestinal mucosa barrier through decreasing the shift of intestinal bacteria endotoxin,lowering cell factor level in plasma and inhibiting ICAM-1 expression in intestinal tissue after obstructive jaundice.