Comparative Study on Efficacy,Weight,Blood Sugar and Blood Lipid between Ziprasidone and Olanzapine in Treatment of First-episode Female Patients with Schizophrenia

Objective To study the influence of ziprasidone and olanzapine on the efficacy,weight,blood sugar and blood lipid in the treatment of first-episode female patients with schizophrenia.Methods A total of 60 female patients with first-episode schizophrenia were randomly divided into 2 groups receiving ziprasidone and olanzapine for 8 w,respectively.Positive and negative symptom scale(PANSS) was used to evaluate the treatment effect and the side effects,They were determined respectively for the efficacy,weight,blood sugar and blood lipid in and blood lipid in the 4th weekend and 8th weekend.Results After treatment,the scores of PANSS of 2 groups were both significantly decreased(P0.01),the ziprasidone's positive symptoms and total score were significantly higher than olanzapine in the 4th weekend(P0.05),but the efficacy between the 2 groups was no significant difference in the 8th weekend(P0.05);Effects on weight,blood glucose,and blood lipid of ziprasidone were significantly less than those of olanzapine,they were significantly different between 2 groups(P0.05).Conclusion Ziprasidone and olanzapine has similar efficacy;Ziprasidone has no effects on weight,blood sugar and blood lipid of first-episode female patients with schizophrenia,but olanzapine has significant effects on weight,blood sugar and blood lipid.