The comparative study of ziprasidone and quetiapine's effects on body weight and glucose and lipid metabolism in first-episode schizophrenic patients

Objective:To investigate the effects of ziprasidone and quetiapine on body weight and glucose and lipid metabolism in schizophrenic patients. Method:82 patients with schizophrenia were randomly divided into two groups each of which ( n = 41) were treated with either ziprasidone or quetiapine. Body weight,fasting blood-glucose and blood lipid including total cholesterol ( CHO) ,triglycerides ( TG) ,low density lipoprotein ( LDL) and high density lipoprotein ( HDL) were measured before and 6 months after the treatment. Results:The ziprasidone group showed no significant difference on body weight,fasting blood-glucose and blood lipid before and after 6 months treatment ( P 0. 05) ,while the quetiapine group showed significant increases on body weight,fasting blood-glucose,CHO and TG ( P 0. 05 or P 0. 01) . Conclusion:Ziprasidone may not affect body weight,blood glucose and blood lipid,while quetiapine may have more effect on body weight,blood glucose and blood lipid.