STUDY ON CORRELATION BETWEEN DIFFERENT SYNDROMES OF CHRONIC GASTRITIS AND APOPTOSIS-REGULATING PROTEIN

Objective :To explore the mechanism of formation of syndrome by observing the correlation between the different syndromes of chronic gastritis and expression of Bax,Bcl-2 and P53 protein.Methods:The syndromes of158 cases of chronic gastritis were differentiated according to clinical symptoms,the expression of Bax,Bcl-2 and P53 protein in patients' gastric mucosa were determined by immunohistochemical method.Results:There was obvious difference between each syndrome of chronic gastritis on the positive area and total optical density of Bcl-2 expression,there was no obvious difference between each syndrome of chronic gastritis on the positive area,average optical density and the total optical density of Bax expression,there was no difference between each syndrome of chronic gastritis on the positive area and the total optical density of P53 expression,the average optical density of P53 expression in dampness-heat of spleen-stomach and deficiency of stomach-yin syndromes was significantly higher than that in the disharmony of liver and stomach syndrome.Conclusion:The formation of each syndrome of chronic gastritis is related to the expression of Bcl-2 and P53.