The Discussion On TCM Syndrome and Molecular Biology Theory of Atrophic Gastritis

Objective: To explore the relationship of syndromes and molecular biology theory in atrophic gastritis. Methods:The 123 patients with atrophic gastritis were identified as the qi and Yin deficient syndrome(45 cases), the spleen kidney Yang deficiency syndrome(38 cases) and the deficiency of blood stasis syndrome(40 cases) according to the distribution of syndromes.And 45 cases of normal healthy specimens of gastric mucosa tissues the same period were chosen as the control group. The gastric mucosa tissue samples and serum EGF content and expression of EGFR mRNA amount were determinate by the immune histochemical method and the relationship between the syndrome of TCM and molecular biology expression was investigated.Results: The serum EGF and EGFR and RNA were all with expression in the control group. Expression increased with the age of disease progression, and comparing with the other three syndromes group, there were statistical differences(P 0.05). The expression of gastric mucosa tissue samples and EGFR mRNA level EGF content in serum in the Qi and Yin group was decreased, and the decreasing index showed obvious differences(P0.05), compared with spleen kidney Yang deficiency syndrome and Qi deficiency blood stasis group. Conclusion: The atrophic gastritis basic pathogenesis is based on the Qi and Yin deficiency. The determination of the serum EGF levels and EGFR mRNA expression can determine different syndromes of atrophic gastritis, and molecular biology gene expression can further determine different syndromes.