Activities of 3 antimicrobial agents against ureaplasma urealyticum and mycoplasma hominis in vitro

Objective To determine the susceptibility of clinical ureaplasma urealyticum(Uu) and mycoplasma hominis(Mh) isolates to tetracyclines,macrolides and quinolones and provide experimental data for clinical therapy. Methods The direct broth dish method was used for susceptibility testing of 195 isolates of Mh to 8 antimicrobial agents.Results For 195 strains of Uu the percentage of susceptibility was as follows:tetracyclin(21.0%),doxycycline (48.2%),minocycline(39.5%),Roxithromycin(79.0%),azithromycin(88.7%),jossamycin(74.9%),ofloxacin(28.2%) and sparfloxacin(64.6%),and for 118 strains of Mh tetracyclin(5.1%),doxycycline(33.9%),minocycline(26.3%),roxithromycin(0.0%),azithromycin(0.0%),jossamycin (89.8%),ofloxacin(70.3%)and sparfloxacin(64.4%).The most susceptible antimicrobial agent to both Uu and Mh from 960 mixed infectious patients was jossamycin (79.2%). Conclusion Susceptibility monitoring of urogenital mycoplasma periodically has important significance in clinical drug treatment.