2006•Zhongliu fangzhi yanjiuRequires access

Anticancer Activities of Curcumin on Nasopharyngeal Carcinoma

Jianhua Yu

Abstract

Objective To study the effects of the curcumin on proliferation in CNE-2Z-H5 cells in vitro and in vivo.Methods The effects of the curcumin on proliferation in CNE-2Z-H5 cells in vitro were studied by MTT assay and trypan blue dye exclusion.Duplicating the model of CNE-2Z-H5 cells implanted tumor in nude mice,then observe the effects of the different doses of curcumin on the growth of implanted tumors.Results The proliferation of CNE-2Z-H5 cells was inhibited significantly by curcumin compared with the control group,which was in dose dependent manner.The results in vivo showed the curcumin could inhibit the growth of CNE-2Z-H5 cells implanted tumor,the inhibited rate arrived at(26.19%)and(59.75%) respectively at the curcumin dose of 25mg/kg and 50mg/kg.Conclusion curcumin could inhibit the proliferation of CNE-2Z-H5 cells in vitro and in vivo,Curcumin might have applicable value in the therapy of NPC,and we have the necessary of continuing researches on curcumin.

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Key concepts: Curcumin, In vivo, Nasopharyngeal carcinoma, In vitro, Trypan blue, Chemistry, Pharmacology, Cancer research