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2011•Zhongliu fangzhi yanjiuOpen access

Effect of Curcumin on Proliferation and Apoptosis of Human Nasopharyngeal Carcinoma CNE-2Z Cells

Ning Sun

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Abstract

Objective To study the effects of Curcumin on proliferation and apoptosis of human nasopharyngeal carcinoma cell CNE-2Z and its possible mechanism.Methods After treatment with Curcumin at various concentrations,the proliferative inhibition of CNE-2Z was observed by MTT assay.The cell cycle influence and cell apoptosis rate were detected by flow cytometry.The expression of Bcl-2 and Bax were detected by Western blot.Results Curcumin could inhibit the proliferation of human nasopharyngeal carcinoma cells CNE-2Z at a time and dose dependent pattern.The cells were blocked at G2/M and S phases.When treated with Curcumin for 24h,the percentage of cell apoptosis was increased.Bcl-2 was down-regulated whereas Bax was up-regulated.Conclusion Curcumin could inhibit the proliferation of CNE-2Z and induce cell apoptosis.

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What this paper is about

Objective To study the effects of Curcumin on proliferation and apoptosis of human nasopharyngeal carcinoma cell CNE-2Z and its possible mechanism.Methods After treatment with Curcumin at various concentrations,the proliferative inhibition of CNE-2Z was observed by MTT assay.The cell cycle influence and cell apoptosis rate were detected by flow cytometry.The expression of Bcl-2 and Bax were detected by Western blot.Results Curcumin could inhibit the proliferation of human nasopharyngeal carcinoma cells CNE-2Z at a time and dose dependent pattern.The cells were blocked at G2/M and S phases.When treated with Curcumin for 24h,the percentage of cell apoptosis was increased.Bcl-2 was down-regulated whereas Bax was up-regulated.Conclusion Curcumin could inhibit the proliferation of CNE-2Z and induce cell apoptosis.

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Available abstract

Objective To study the effects of Curcumin on proliferation and apoptosis of human nasopharyngeal carcinoma cell CNE-2Z and its possible mechanism.Methods After treatment with Curcumin at various concentrations,the proliferative inhibition of CNE-2Z was observed by MTT assay.The cell cycle influence and cell apoptosis rate were detected by flow cytometry.The expression of Bcl-2 and Bax were detected by Western blot.Results Curcumin could inhibit the proliferation of human nasopharyngeal carcinoma cells CNE-2Z at a time and dose dependent pattern.The cells were blocked at G2/M and S phases.When treated with Curcumin for 24h,the percentage of cell apoptosis was increased.Bcl-2 was down-regulated whereas Bax was up-regulated.Conclusion Curcumin could inhibit the proliferation of CNE-2Z and induce cell apoptosis.

Key concepts: Curcumin, Nasopharyngeal carcinoma, Apoptosis, Flow cytometry, Cell growth, Chemistry, Cell cycle, Cell

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Effect of Curcumin on Proliferation and Apoptosis of Human Nasopharyngeal Carcinoma CNE-2Z Cells — Research Paper | ScholarLens