Influence of astragaloside IVon NO,SOD and MDA in methamphetamine-dependence rat brain

Objective To explore the intervention and protective effects of astragaloside Ⅳ on brain tissue in chronic methamphetamine dependent rat model. Methods The chronic methamphetamine dependent rat model was established by intragastric administration of astragasloside Ⅳ.NO,MDA content and SOD activity in hippocampus were detected in different groups. Results In chronic methamphephetamine group,the expression level of NO and MDA was increased,SOD activity was decreased,compared with the control group,there was statistically significance(P0.01).In astragalosideⅣ high dose group(20 mg/kg),the content level of MDA was decreased and SOD activity was increased,there was statistically significance,compared with chronic methamphephetamine group(P0.01). Conclusion Astragaloside Ⅳ can reduce the NO and MDA content in the hippocampus MA chronic infected rats,increases SOD activity.On the central nervous system damage,Astragaloside Ⅳ has a certain role in the intervention and protection by antioxidant function,and has protective effect on brain tissue.