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2007•Zhongguo yaowu yilaixing zazhiRequires access

CHANGE OF NO,SOD AND MDA IN METHAMPHETAMINE-TREATED RAT BRAIN AND THEIR CORRELATION

Pingming Qiu

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Abstract

Objective:To study the change of nitric oxide(NO),super oxide dismutase(SOD)and malondialdehyde(MDA)in rat brain after methamphetamine injection.Methods:Rats were randomly divided into control group(A)and experimental group(B).Group B was injected with MA,and Group A was injected with saline.The levels of NO,SOD,MDA in the brain of rats treated with methamphetamine were observed and the relationship among them was studied.Results:NO content and MDA content in hippocampal and striaturn increased,SOD content in hippocampal and striaturn decreased,and there were significant differences in the level of NO,SOD and MDA between Group A and Group B(P0.01).Conclusion:Methamphetamine can cause an increase in the contents of NO and MDA,and decrease in SOD activity.This might be an important mechanism of MA induced damage in central nervous system that might participate in the MA neurotoxicity.

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What this paper is about

Objective:To study the change of nitric oxide(NO),super oxide dismutase(SOD)and malondialdehyde(MDA)in rat brain after methamphetamine injection.Methods:Rats were randomly divided into control group(A)and experimental group(B).Group B was injected with MA,and Group A was injected with saline.The levels of NO,SOD,MDA in the brain of rats treated with methamphetamine were observed and the relationship among them was studied.Results:NO content and MDA content in hippocampal and striaturn increased,SOD content in hippocampal and striaturn decreased,and there were significant differences in the level of NO,SOD and MDA between Group A and Group B(P0.01).Conclusion:Methamphetamine can cause an increase in the contents of NO and MDA,and decrease in SOD activity.This might be an important mechanism of MA induced damage in central nervous system that might participate in the MA neurotoxicity.

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Available abstract

Objective:To study the change of nitric oxide(NO),super oxide dismutase(SOD)and malondialdehyde(MDA)in rat brain after methamphetamine injection.Methods:Rats were randomly divided into control group(A)and experimental group(B).Group B was injected with MA,and Group A was injected with saline.The levels of NO,SOD,MDA in the brain of rats treated with methamphetamine were observed and the relationship among them was studied.Results:NO content and MDA content in hippocampal and striaturn increased,SOD content in hippocampal and striaturn decreased,and there were significant differences in the level of NO,SOD and MDA between Group A and Group B(P0.01).Conclusion:Methamphetamine can cause an increase in the contents of NO and MDA,and decrease in SOD activity.This might be an important mechanism of MA induced damage in central nervous system that might participate in the MA neurotoxicity.

Key concepts: Malondialdehyde, Methamphetamine, Neurotoxicity, Hippocampal formation, Nitric oxide, Superoxide dismutase, Dismutase, Saline

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