2010•Guiding Journal of Traditional Chinese Medicine and PharmacyRequires access
Study on Preparation and in vitro Release of Marine Sustained-Release Tablets
Yan Huang
Open publisher page 0 citations
Abstract
Objective: To prepare 12-hours Sustained-Release Marine Tablets,and to evaluate its cumulative release ratio in vitro.Methods: Marine Sustained-Release Tablets were prepared with HPMC and H-HPC as matrix,The cumulative release ratio in vitro the tablets was determined.Results: The release behavior of the prepared sustained-release tablets followed the Higuchi equation,comparing to the ordinary tablet,Marine Sustained-Release Tablets had an obvious sustained-release effect,and the correlation between the in vitro release and the in vivo absorption was good.Conclusion: Matrine in vitro release of sustained-release tablets was slow,steady,to the design requirements,this could help to enhance Oxymatrine efficacy,reduce side effects with low toxicity.