2007•Chinese Journal of PharmaceuticsRequires access
Study on preparation and release of glipizide sustained- release tablets in vitro
Li Li
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Abstract
Objective To prepare glipizide sustained release tablets,and evaluate its release in vitro.Methods The tablets were prepared with HPMC as matrix material and optimized by orthogonal test.The similarity factors(f2) were used to calculated similarity of release profiles of test and reference tablets.The effect of hardness of tablets,pH of release medium and the speed of paddle on the release profile was investigated.Results The sustained-release tablets were prepared with HPMC K4M and HPMC K100LV as basic matrix material.The release pattem of glipizide was properly described by Higuchi equation.The release rate was slightly affected by pH value,the hardness of the tablets and the speed of paddle.Conclusions The selected formulation of glipizide sustained-release tablets is reasonable and the drug release in vitro confirms the requirements of the sustained-release formulation.