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Preparation and release mechanism of Metlazone Sustained Release Tablets

Wang Chun-long

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Abstract

Objective To prepare Metlazone Sustained Release Tablets,and study their release mechanisms.Methods The effects of many factors,including formulation and technique on the release behavior of Metlazone Sustained Release Tablets were investigated.Based on the comprehensive single-factor tests,Metlazone Sustained Release Tablets were prepared with HPMC 4000 cps as matrix material,and HPMC 5 cps as porogen.The formulations were optimized by orthogonal design with the accumulative release amounts of 2,4,and 7 h has the evaluation target.Results The amounts and proportions of HPMC were major factors on release of Metlazone Sustained Release Tablets.The release behaviors of tablets followed Ritger-Peppas kinetics,and the drug was released by diffusion and corrosion mechanism.Conclusion The preparations of Metlazone Sustained Release Tablets has good repeatability and the release in vitro could meet the requirements.

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What this paper is about

Objective To prepare Metlazone Sustained Release Tablets,and study their release mechanisms.Methods The effects of many factors,including formulation and technique on the release behavior of Metlazone Sustained Release Tablets were investigated.Based on the comprehensive single-factor tests,Metlazone Sustained Release Tablets were prepared with HPMC 4000 cps as matrix material,and HPMC 5 cps as porogen.The formulations were optimized by orthogonal design with the accumulative release amounts of 2,4,and 7 h has the evaluation target.Results The amounts and proportions of HPMC were major factors on release of Metlazone Sustained Release Tablets.The release behaviors of tablets followed Ritger-Peppas kinetics,and the drug was released by diffusion and corrosion mechanism.Conclusion The preparations of Metlazone Sustained Release Tablets has good repeatability and the release in vitro could meet the requirements.

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Available abstract

Objective To prepare Metlazone Sustained Release Tablets,and study their release mechanisms.Methods The effects of many factors,including formulation and technique on the release behavior of Metlazone Sustained Release Tablets were investigated.Based on the comprehensive single-factor tests,Metlazone Sustained Release Tablets were prepared with HPMC 4000 cps as matrix material,and HPMC 5 cps as porogen.The formulations were optimized by orthogonal design with the accumulative release amounts of 2,4,and 7 h has the evaluation target.Results The amounts and proportions of HPMC were major factors on release of Metlazone Sustained Release Tablets.The release behaviors of tablets followed Ritger-Peppas kinetics,and the drug was released by diffusion and corrosion mechanism.Conclusion The preparations of Metlazone Sustained Release Tablets has good repeatability and the release in vitro could meet the requirements.

Key concepts: Controlled release, Immediate release, Chemistry, Diffusion, Chromatography, Matrix (chemical analysis), Kinetics, Repeatability

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