EXPERIMENTAL OBSERVATION ON GERMICIDAL EFFICACY AND TOXICITY OF COMPOUND DISINFECTANT OF BEE GLUE

Objective:In order to know germicidal efficacy and toxicity of compound disinfectant of bee glue.Methods:The carrier quantitative germicidal test and animal test were used to observe its germicidal effcacy and toxicity.Results:The result showed that dilute solution formed by mixing its stock solution with water at a ratio of 1∶6 with a 15 minute contact time could kill 100% of Escherichia coli and staphylo coccus aureus on cloth strip and the dilute solution formed by adding water at a ratio of 1∶2 with a 20 miunte contact time could kill 99.96%～99.98% of Candida albicans on cloth strip.The germicidal efficacy decreased due to presence of organic substances or after storing at 54 ℃ for 14 days.The oral LD_ 50 of its stock solution in mice was 5 000 mg/kg and the integrated score of skin irritative reaction in rabbits was zero,so it belongs to actually non-toxic and non-irritative substance.Conclusion:Compound disinfectant is a kind of original disinfectant which has better germicidal efficacy and could be safely used.