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2011•Journal of Clinical StomatologyRequires access

The study on the effects of Interleukin-1β and dexamethasone on the proliferation of cultured fibroblasts

Sha Hua

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Abstract

Objective:To detect the influence of IL-1β and DEX on the proliferation of cultured fibroblasts from normal oral mucosa and oral lichen planus mucosa.Method:IL-1β and DEX of three concentration gradient were set and added to cultured fibroblasts of normal oral mucosa and oral lichen planus mucosa.MTT was adopted to assess the effects of IL-1β and DEX on the proliferation of fibroblasts.Result:IL-1 can promote the proliferation of both oral lichen planus fibroblasts and normal oral mucosa fibroblasts,and it is concentration-dependent.Otherwise,DEX inhibited the proliferation of the two kinds of fibroblasts,and it's also concentration dependent.Conclusion:Interleukin-1 could promote fibroblast proliferation,and dexamethasone inhibit fibroblast proliferation.

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What this paper is about

Objective:To detect the influence of IL-1β and DEX on the proliferation of cultured fibroblasts from normal oral mucosa and oral lichen planus mucosa.Method:IL-1β and DEX of three concentration gradient were set and added to cultured fibroblasts of normal oral mucosa and oral lichen planus mucosa.MTT was adopted to assess the effects of IL-1β and DEX on the proliferation of fibroblasts.Result:IL-1 can promote the proliferation of both oral lichen planus fibroblasts and normal oral mucosa fibroblasts,and it is concentration-dependent.Otherwise,DEX inhibited the proliferation of the two kinds of fibroblasts,and it's also concentration dependent.Conclusion:Interleukin-1 could promote fibroblast proliferation,and dexamethasone inhibit fibroblast proliferation.

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Available abstract

Objective:To detect the influence of IL-1β and DEX on the proliferation of cultured fibroblasts from normal oral mucosa and oral lichen planus mucosa.Method:IL-1β and DEX of three concentration gradient were set and added to cultured fibroblasts of normal oral mucosa and oral lichen planus mucosa.MTT was adopted to assess the effects of IL-1β and DEX on the proliferation of fibroblasts.Result:IL-1 can promote the proliferation of both oral lichen planus fibroblasts and normal oral mucosa fibroblasts,and it is concentration-dependent.Otherwise,DEX inhibited the proliferation of the two kinds of fibroblasts,and it's also concentration dependent.Conclusion:Interleukin-1 could promote fibroblast proliferation,and dexamethasone inhibit fibroblast proliferation.

Key concepts: Oral mucosa, Fibroblast, Oral lichen planus, Dexamethasone, Cell growth, MTT assay, Chemistry, Interleukin

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