Relation of Survivin,CD_(44v6),MMP-2 Protein Expression to Invasion and Metastasis in Cervical Carcinoma

Objective: To investigate the expression of survivin,CD_(44v6) and matrix metalloproteinase(MMP-2) in the development of cervical cancer and their relationship with the invasive and metastatic capacity of cervical carcinoma.Methods: The expression of survivin,CD_(44v6) and MMP-2 was examined by immunohistochemical method and color pathological image computer analysis system in 10 cases of normal cervical epithelia,10 cases of cervical carcinoma in situ,40 cases of invasive squamous cell carcinoma of cervix and 11 cases of invasive adenocarcinoma of cervix.The relationship between those expression outcomes and to the characteristics of clinical pathology of cervical carcinoma was analyzed statistically.Results: It was found that the positive level of survivin,CD_(44v6) and MMP-2 expression followed this increasing order: normal cervical epithelium→ cervical carcinoma in situ→invasive carcinoma of cervix(P0.05).The positive expression of survivin,CD_(44v6) and MMP-2 in patients under 35 years old or with pelvic lymph node metastasis,intravascular involvement,stroma involvement were significantly higher than those in the cases without them.Survivin was expressed significantly higher in squamous cell carcinoma cases than in adenocarcinoma cases,but on the contrary,CD_(44v6) and MMP-2 were expressed higher in adenocarcinoma cases(P0.05).Conclusions: The positive expression of survivin,CD_(44v6) and MMP-2 in invasive carcinoma of cervix might play an important role in the development,lymph node metastasis,intravascular and stroma involvement of neoplastic cells,and they have close relationship with clinical behavior of cervical carcinoma.