Expression and Significance of CD_(44v6) and MMP-2 in Cervical Carcinoma

Objective To study the expression and its clinical significance of CD 44v6 and MMP-2 in cervical carcinoma.Methods To detect the expression of CD 44v6 and MMP-2 in 15 cases of chronic cervicitis,34 cases of CIN and 53 cases of cervical carcinoma by immunohistochemical techniques.Results The expression rates of CD 44v6 and MMP-2 were gradually increased with the progress cervical lesions.The positive expression rates of CD 44v6 and MMP-2 in chronic cervicitis,CIN and cervical carcinoma were 0%,35.71%,64.71% and 0%,28.57%,68.63%,respectively.The expression of CD 44v6 and MMP-2 were correlated with lymph node metastasis,but there was no relationship with clinical stage.The CD 44v6 expression was positive correlation to MMP-2 expression in cervical carcinoma (r=0.385,P0.01).Conclusion The expression of CD 44v6 and MMP-2 was correlated with development,invasion and metastasis of human cervical carcinoma.Examination of expression of those two proteins may be helpful to early screen and judge tumor metastasis of cervical carcinoma.