Relationship between insulin resistance and plasma endothelin in hypertension patients

To explore the relationship between plasma endothelin and hypertension insulin resistance,and the improvement of insulin resistance in hypertension patients treated with captopril and l-amlodipine,25 patients with primary hypertension and impaired glucose tolerance were selected and treated by captopril and l-amlodipine.Systolic pressure,diastolic pressure, fasting blood glucose,insulin and insulin antibody were measured before and after treatment and compared with healthy controls.The results showed that the plasma ET-1 level in hypertension group was significantly higher than that of healthy controls(P0.01),and he plasma ET-1 level was positively correlated with FPG,FINS,Anti-INS,HOMA-IR.The systolic pressure,diastolic pressure,fasting blood glucose,insulin,insulin antibody and insulin resistance index in hypertension patients were decreased significantly after treatment(P0.05).There is a good correlation between endothelin and insulin resistance index in hypertension patients.Captopril and l-amlodipine had obvious improvement effect on insulin resistance in hypertension patients.