2010•Zhongguo yiyuan ganranxue zazhiRequires access
Drug resistance analysis of extended-spectrum β-lactamases producing Escherichia coli and Klebsiella pneumoniae.
Xiaofei Li, Yulin Chen, Yang Hui-xian, Hong Chen, Wang Jun-feng, Ju Zhang
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Abstract
OBJECTIVE To investigate the drug resistance of extended-spectrum β-lactamases(ESBLs) producing Escherichia coli and Klebsiella pneumoniae,providing evidence for the clinical rational administration of antimicrobial drugs.METHODS Using Microscan WalkAway40 S1 system and special plate NC21,ESBLs-producing E.coli and K.pneumoniae were detected from clinic specimens and drug sensitivity tests were carried out.RESULTS Among 341 isolates,150 strains(43.99%) were isolated producing ESBLs,with 49.79%(118/237) of E.coli and 30.77%(32/104) of K.pneumoniae.ESBLs-producing bacteria showed high resistance to a great number of antimicrobial drugs,and relatively low resistance to imipenem,piperacillin/tazobactam,amikacin and cefoxitin.CONCLUSIONS Detection of ESBLs prodution and susceptibility to antibiotics,in time can provide guidance to rational clinical administration of drugs.The imipenem,piperacillin/tazobactam,amikacin and cefoxitin could be effectively used in treatment of ESBLs-producing bacteria infectioons cases.