Drug resistance analysis on E.coli and K.pneumoniae produced extended spectrum β-lactamases

Objective To investigate the resistance and distributing situation of extended-spectrum β-lactamases (ESBLs)-producing strains in E.coli and K.pneumoniae in our hospital during last year,so as to guide the clinical drug use.Methods 396 strains of E.coli and K.pneumoniae were detected and analyzed by K-B agar diffusion method and confirmed test.Results The positive rate of ESBLs-producing among E.coli and K.pneumoniae was 52.7% and 35.7%,respectively. ESBLs had lower drug resistant rate to imipenem,piperacillin/sulbactam,cefoxitin and amikacin.Conclusion It is very important to pay attention to the determination of ESBLs-producing strains.We should reasonably use drug according to the result of susceptibility test.The ideal antibacterial drugs for treating ESBLs-producing bacteria are carbapenems,cefoxitin,complex antibiotics containing β-lactamases inhibitor and amikacin.