Surveillance of bacterial resistance from hospitals in Shanghai in 2003

ObjectiveTo investigate the bacterial resistance of clinical isolates from hospitals in Shanghai in 2003.MethodsAntimicrobial susceptibility testing of clinical isolates were performed using Kirby-Bauer methods and the results were analysed according to NCCLS(2003).ResultsOf 22 158 clinical isolates,gram positive organisms accounted for 33.6% (7 449/ 22 158),Gram negative organisms for 66.4% ( 14 709/ 22 158).In Staphylococcus aureus(MRSA) and coagulase negative Staphylococcus,MRSA and MRCNS accounted for 59.8% and 80.3% respectively.Penicillin-nonsusceptible S.pneumonine (PISP+PRSP) strains were 62.8% and 13.6% from children and adult respectively.ESBLs-producing strains accounted for 33.6% and 44.2% in E.coli and Klebsiella spp..Vancomycin and teicoplanin are the most potent antimicrobial agent against gram positive cocci.No strain of Staphylococcus spp.and Enterococcus spp.resistant to both antimicrobial agents has been found yet.Imipenem and meropenem are the most potent antimicrobial agents tested against strains of Enterobacteriaceae and Acinetobacter spp.,resistant rates of which were the lower,but resistant rates of P.aerogenosa were 24.5% and 16.9%. S.maltophilia and Burkholderia spp.to the both of imipenem and meropenem were very high resistant,but sensitive to cefoperazone-sulbactam,ciprofloxacin,ticarcillin-clavulanic acid and SMZ-TMP.ConclusionsThe data will be useful for reasonably choosing antimicrobial agents in the treatment of infections caused by pathogenic bacteria.