Influence of type B aortic dissection on coagulation function

Objective To explore the changes of blood coagulation function and clinical significances in type B Aortic Dissection(AD). Methods 99 patients with type B AD group,95 persons in healthy control group were selected respectively(NC).The detection and analysis of international normalized ratio(INR),activated partial thromboplastin time (APTT),thrombin time (TT),fibrinogen (Fib) and D-dimer (D-D) were conducted. Results INR,APTT,FIB,DD in AD group significantly increased compared with NC group,TT decreased respectively (P0.01).Subacute and chronic AD showed a significant increase in INR and FIB,compared with acute group,P0.01. Conclusions AD is characterized by activation of both coagulation and fibrinolysis,resulting in an imbalance between coagulation and fibrinolysis that leading to a hypercoagulation state.