Examination and clinical significance of coagulation function of patients with Type B Aortic Dissection

Objective To explore the changes of blood coagulation function and clinical significances in type B aortic dissection(AD).Methods 99 patients with type B aortic dissection group,95 persons in healthy control group were selected respectively(NC) and the detection and analysis of international normalized ratio(INR),activated partial thromboplastin time(APTT),thrombin time(TT),fibrinogen(Fib) and D-dimer(D-D) were conducted.Results INR,APTT,FIB,DD in AD group significiantly increased compared with NC group,TT decreased respectively(P0.01).Subact and chronic aortic dissection showed a significant increase in INR,Fib,compared with acute group.Conclusion AD is characterized by activation of both coagulation and fibrinolysis,resulting in an imbalance between coagulation and fibrinolysis leading to a hypercoagulation state.