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1999•The Chinese Journal of Clinical PharmacologyRequires access

A CLINICAL TRIAL OF ETOFESALAMIDE OINTMENT IN THE TREATMENT OF NEURODERMATITIS

Changhai Ding

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Abstract

To study the efficacy and safety of 5% etofesalamide ointment in the treatment of neurodermatitis, a randomized, double blind, controlled clinical trial was performed. Fifty patients were given etofesalamide ointment and other 50 patients were given 0.025% fluocinolone acetonide ointment (FAO) thinly on the surface of suffered skin 3 times a day for 4 weeks. The results indicated that the effective rate of etofesalamide ointment was 52% at 2 weeks and 78% at 4 weeks, respectively. And FAO was 40% at 2 weeks and 72% at 4 weeks respectively. The adverse reaction of both drugs were slight and were noted only in 2%. The results suggest that etofesalamide ointment may have an efficacy and tolerance similar to that of FAO in the treatment of neurodermatitis.

About this research paper

What this paper is about

To study the efficacy and safety of 5% etofesalamide ointment in the treatment of neurodermatitis, a randomized, double blind, controlled clinical trial was performed. Fifty patients were given etofesalamide ointment and other 50 patients were given 0.025% fluocinolone acetonide ointment (FAO) thinly on the surface of suffered skin 3 times a day for 4 weeks. The results indicated that the effective rate of etofesalamide ointment was 52% at 2 weeks and 78% at 4 weeks, respectively. And FAO was 40% at 2 weeks and 72% at 4 weeks respectively. The adverse reaction of both drugs were slight and were noted only in 2%. The results suggest that etofesalamide ointment may have an efficacy and tolerance similar to that of FAO in the treatment of neurodermatitis.

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Method / approach

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Available abstract

To study the efficacy and safety of 5% etofesalamide ointment in the treatment of neurodermatitis, a randomized, double blind, controlled clinical trial was performed. Fifty patients were given etofesalamide ointment and other 50 patients were given 0.025% fluocinolone acetonide ointment (FAO) thinly on the surface of suffered skin 3 times a day for 4 weeks. The results indicated that the effective rate of etofesalamide ointment was 52% at 2 weeks and 78% at 4 weeks, respectively. And FAO was 40% at 2 weeks and 72% at 4 weeks respectively. The adverse reaction of both drugs were slight and were noted only in 2%. The results suggest that etofesalamide ointment may have an efficacy and tolerance similar to that of FAO in the treatment of neurodermatitis.

Key concepts: Neurodermatitis, Medicine, Fluocinolone acetonide, Dermatology, Clinical trial, Adverse effect, Clinical efficacy, Randomized controlled trial

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