The Clinic Observation to Fluoxetine though Treating Parkinson's with Depression

Objective:To explore the clinical effect of fluoxetine in the patients with Parkinson's disease(PD)and depression.Methods:43 cases of PD with depression were randomly divided into therapy group(23 cases) and control group(20cases),On the same basic treatment,the therapy group was treated with fluoxetine(20 mg/d) additionally.Disease severity was evaluated by the unified Parkinson's disease rating scale(UPDRS) and the level of depression was evaluated by 17-item Hamilton-Depression Rating Scale(HAMD-17) before and after 8 weeks treatment.Results:At the end of 8th week,the scores of UPDRS and HAMD in the therapy group were significantly reduced,and the total effective antidepressant efficacy was significantly higher than that of control group.Conclusion:Fluoxetine in the treatment of PD patients with depression,can not only effectively improve the depressive state,but restore movement disorders obviously.Fluoxetine plays a positive role in improving the patient's life quality.