Clinical research on fluoxetine treating Parkinson's disease with depression

【Objective】 To investigate the clinical efficacy and safety of Fluoxetine in the treatment of Parkinson disease(PD).【Methods】 100 patients with PD were assessed by Haimihon Depression Rating Scales(HAMD),Self-Rating Depression Scale(SDS).After assessing,64 patients with depression were randomly divided into control group(n =32) and therapy group(n =32).The therapy group was treated with Fluoxetine and the control group was treated with usual therapy.Then the curative and side effects in the all patients were assessed at the end of the 2nd、4th and 6th weeks after the initiation of the study.【Results】 There was significant difference in the total effective rate of anti-depression and anti-PD in the control group and the therapy group(P 0.01).The side effects in the two groups were slight,and the incidences of all the factors in SERS between the two groups had no significant differences(P 0.05).【Conclusions】 Fluoxetine is effective and safe in adjuvant treatment of PD accompanied by depression.