Diagnostic value of investigationg of CTNI.CK and CK-MB in the early acute mvocardial diseases

[Objective] To investigate the specific change of cardiac troponin I(CTNI) ,creatine kinase(CK) , creatine kinase-MB(CK-MB)in acute myocardial infraction (AMI) and unstable angina pectoris ( UAP) ,to provide an early diagnostic window and detection in the course of diseases. [Methods] Serum from 56 patients with coronary heart disease (AMI) ,43 patients with unstable anigina pectoris (UAP) and 50 healthy people was examined for CTNI,CK,and CK-MB, and respective comparison with each other was made. To start the test with Beckman Access auto immunosobant experment and OLYMPUS AU400 auto biochemical analysis experiment by immunitive chemical methods. [Results] The sensitivity and specificity of cardiac damage were 92. 98% and 97. 96% in AMI;72. 36 and 78. 06% in UAP,CK wee 48% and 44% ,CK-MB were 76% and 55. 5%. The positive rates of CTNI in AMI and UAP were significantly higher than those of CK-MB and CK. [ Conclusion ] The serum level of CTNI can closely reflect the extent of myoeardial damage in AMI, it provides an early diagnosric window for detection of AMI if examined with CK-MB and CK. Serum level of CTNT,CK and CK-MB are markers with high sensitivity and specificity for AMI and can aid in the early diagnosis of acute myocardial disease.