Clinical study on myocardial injury diagnosis of the serum CK, CK-MB, cTnI to the infant patients

Objective To explore the diagnostic value of serum CK, CK-MB, cTnI to myocardial injury in the infant patients. Methods Determination was made to serum CK, CK - MB and cTnI for 196 examples and 102patients with electrocardiogram and clinical expression with and without a myocardial impairment performance of no myocardial injury patients and normal children as control. Results Three indexes of the myocardial injury group were CK (236.2 ± 127.2) U/L; CK-MB (32.2 ± 12.7) U/L, cTnI (0.24 ± 0.13) ng/ml respectively, significantly higher than those in the group without myocardial impairment performance and control group(P ＜ 0.01), but the specificity and sensitivity were different, and the sensitivity and accuracy of the Joint inspection attained 93.4% and 80.5%, both data fields had significant improves (P ＜ 0.05). Conclusions The reaction of the serum CK, CK-MB and the cTnI for infant patients myocardial injury showed that CK, CK-MB specificity is not high, at the same time,we should consider the activity increasing of the pure CK, CK-MB may result from physiology, specimens and reagents, without clinical diagnostic value. The cTnI has the highest specificity, but in myocardial mild damage the sensitivity is not high, so the diagnosis to infant patients myocardial injury should combine with these three factors, as well as the electrocardiogram and clinical expression for comprehensive confirmation. Key words: Myocardial injury;  Creatine kinase(CK);  Creatine kinase isozyme-MB(CK-MB);  Troponin Ⅰ(cTnI);  Joint survey