Significance of cardiac troponin T and troponin I in the early diagnosis of myocardial infarction

Objective:To investigate the early diagnostic value and significance of cardiac troponin T(cTnT) and troponin I(cTnI) in acute myocardial infarction (AMI).Methods:Serum from 100 patients with coronary heart disease(AMI) 50 cases, unstable angina pectoris (UAP) 50 cases and 20 healthy controls were examined for cTnT, cTnI, CK and CK MB by enzyme immunosorbart assay and other physiochemical methods.Results:①The sensitivity and specificity of cardiac damage were 80% and 90% for cTnT; 85% and 92% for cTnT; 75% and 75% for CK MB; 92% and 61% for CK respectively. ② In AMI group, the concentration of cTnT and cTnI rose up to 17.5 ± 5.7 times and to 16.2 ± 4.8 times, which were significantly higher than that of CK( 7.6 ± 3.1 ) times and CK MB ( 6.5 ± 2.9 ) times (P 0.01 ). ③ In the 3 h after AMI, the positive rates of cTnT ( 50.0 %) and cTnI ( 40.0 %) were significant higher than CK ( 24.0 %) and CK MB ( 20.0 %). In the 5 day after AMI, the positive rates were 70% for cTnI; 66% for cTnT; 4% for CK MB and 8% for CK. Conclusion:The serum level of cTnT and cTnI can closely reflect the extent of myocardial damage in AMI. It provides a early diagnostic window for detection of AMI than CK and CK MB. Serum level of cTnT and cTnI are markers with high sensitivity and specificity for AMI and can aid in the early diagnosis of AMI.