Accuracy of colposcopy biopsy in diagnosis of cervical intraepithelial neoplasia and associated factors of missed diagnosis for cervical cancer

Objective:To analyze the accuracy of colposcopy biopsy in the diagnosis of cervical intraepithelial neoplasia(CIN)and the associated factors in missed diagnosis of cervical cancer.Methods:Clinical data of 118 patients with CIN diagnosed by biopsy under colposcopy were retrospective analyzed.All patients underwent loop electrosurgical excision procedure(LEEP),with the postoperative pathology as the gold standard,the accuracy of biopsy under colposcopy in the diagnosis of CIN was observed,and related factors of missed diagnosis of cervical cancer were analyzed.Results:1The coincidence rate of biopsy under colposcopy conforming to pathological examination after LEEP operation in 101 patients was 85.59%,and the pathological leve of 23(19.49%)patients increased,including 17(14.41%)cases of the missed diagnosis of invasive carcinoma.2The missed diagnosis rates of cervical cancer in patients with age not less than 50 years old,HSIL of cytology detection,CINⅠ of colposcopic pathology,unsatisfied quality of colposcopy image,only one biopsy specimen,less than 1/2of cervical lesion area were higher(Pall0.05).HSIL of colposcope pathology,the image quality of colposcopy,the number of biopsy specimen,and the size of cervical lesion were the key factors influencing the diagnosis of cervical cancer by colposcopy biopsy(P0.05).Conclusion:Colposcopy is intuitive for diagnosis of cervical lesions,but still not accurate enough for the diagnosis of CIN.It is importance to reduce the rate of missed diagnosis by strengthening the identification of cervical cytology,improving operational skills of colposcopy,promoting the image quality,especially taking more biopsy.