Evaluation on the Accuracy of Histopathology after LEEP and Colposcopy Cervical Biopsy for the Diagnosing of Cervical Intraepithelial Neoplasia

Objective To compare the difference between histopathology after LEEP and colposcopy cervical biopsy,and to evaluate the accuracy of diagnosing cervical intraepithelial neoplasia with colposcopy cervical biopsy.Methods 315 patients with cervical diseases were examined by colposcopy cervical biopsy and pathology after loop electrosurgicai excision procedure.Results Coincidence rate of colposcopic cervical biopsy and histopathology after LEEP was 57.15%(180/315),under diagnosis rate was 20.95%(66/315) and over diagnosis rate was 21.90%(69/315);Coincidence rate of CINI was 76.67%(23/30),missed 2 cases of CINⅡ/CINⅢand there was no misdiagnosed carcinoma in situ and tiny invasive cancer.Coincidence rate of CINⅡ/ CINⅢ(including carcinoma in situ) was 56.67%(63/111),missed 33 cases of invasive carcinoma(33/111).High grade of CIN diagnosed by colposcopy and cytological examination≥HSIL were risk factors of missed diagnosis(P0.05).Conclusion The accuracy of diagnosing cervical intraepithelial neoplasia with colposcopy cervical biopsy is not satisfying,there are risks of misdiagnosis tiny invasive cancer.Patients with high-grade CIN diagnosd by colposcopic cervical biopsy should receive LEEP to avoid missed diagnosis of cervical carcinoma.