Comparative study of clomipramine and fluoxetine in treatment of child depression

Objective:To compare the efficacy and side effects of clomipramine and fluoxetine in treatment of childhood depression.Methods:One hundred and thirty patients with depression were randomly divided into 2 groups treated with clomipramine and fluoxetine respectively for 8 weeks.The efficacy was evaluated with Self-Rating Depression Scale(SDS) and the side effects were evaluated with treatment symptome scale(TESS).Results:The effective rate of clomipramine group and fluoxetine group were 83.1% and 87.7% respectively,which had no remarkable differences between the two groups.However,the total effective rate of clomipramine group was significantly higher than that of fluoxetine group after two-week treatment.The side effects of both groups were few and light.Conclusions:Both clomipramine and fluoxetine are effective in treatment of child depression with few side effects.