Impact of small dose aspirin on gastrointestinal mucosa in the aged

Objective To investigate the effects of small dose of aspirin on gastrointestinal mucosa in the aged.Methods Eighty-two old patients administered with small dose Asplin(50～100 mg·d~(1))were divided into two groups,administration group of below 3 months and group of over 3 months.Gastroscopy and detection of Helicobacter pylori(Hp) were performed in observation group and compared with those in control group(60 cases of health).Results Scores of injury of mucosa in body of stomach,gastric antrum and duodenal bulb in observation group were obviously higher than those in control group(P0.05).Scores of injury of mucosa in body of stomach,gastric antrum and duodenal bulb in group of over 3 months were obviously higher than those in group of below 3 months(P0.05).Scores of injury of mucosa in body of stomach,gastric antrum and duodenal bulb in observation groups of patients with positive and negative Hp were obviously higher than those in control group.(P0.05).Scores of injury of mucosa in body of stomach,gastric antrum and duodenal bulb in observation group of positive Hp were obviously higher than those in group of negative Hp(P0.05).Conclusion Small dose aspirin was damaged to gastrointestinal mucosa in the aged.The longer time of administration and the severe is injury.Injury of gastrointestinal mucosa caused by positive Hp is severe than that caused by negative Hp.