A Clinical Observation on the Relationship Between Shimofuri Lesion with Helicobacter Pylori Infection

Objective To learn the roles of Helicobater pylori(Hp)colonization in shimofuri lesion formation of degestive tract and its transformation.Method Infective rate of Hp in biopsy specimens of gastric antrum and duodenum,degree of inflammation of the duodenal bulb mucosas were measured,and analyzed relationship of these indexes with Hp colonization in duodenal bulb mucosas,all of patients with shimofuri lesion were randomly divided into ranitidine suppressing acid group(ranitidine group) and anti-Hp therapy group(anti-Hp group),then two groups were secondly observed with gastroscope.Results The positive rate of Hp colonization in duodenal bulb was significantly difference in various phases of the disease(P＜0.05),it was correlated to the density of Hp in gastric antrum(rs＝0.566，P＜0.05)：The inflammation degree between various duodenal mucosa lesion was different(P＜0.05) and correlated with the Hp infection in duodenal mucosas(rs＝0.5615,P＜0.05).twenty-six cases of Hp-infecting shimofuri lesions were repeated examined by endoscopy and the endoscopic findings were five cases of shimofuri lesion(one case complicated duodenal ulcer)in the ranitidine group,but it was zero in anti-Hp group(P＜0.05).Conclusion The results suggest that the shimofuri lesion is associated with Hp colonization in duodenal bulb,and also related to the Hp density in gastric antrum.