Effect of Ki-67 expression and Helicobacter pylori in aspirin associated gastric mucosa injury diseases

Objective To explore the effects of Ki-67 expression and Helicobacter pylori(H.pylori) in aspirin associated gastric mucosa injury diseases.Methods According to the result of gastroscopic,136 patients with aspirin associated gastric mucosa injury diseases were divided into three groups: bleeding group,ulcer group and gastritis group.All patients were detected with rapid urease test(RUT),Giemsa stain and 13C-Urease breath test(13C-UBT).According to the results of above tests,the patients were divided into H.pylori infection group and H.pylori non-infection group.The expression of Ki-67 protein was examined in 136 patients with aspirin associated gastric mucosa injury diseases samples by immunohistochemical technique.Results Immunohistochemical stain scores of Ki-67 in normal gastric mucosa was 0.125±0.354.There were 3.916 ±1.676,2.174 ± 1.527 and 1.394±0.899 in immunohistochemical stain scores in bleeding group,ulcer group and gastritis group,respectively.Compared with ulcer group and gastritis group,significant elevated of Ki-67 expression was shown in bleeding group(P0.05).The expression of Ki-67 in the H.pylori infection group was significantly higher than that in the H.pylori non-infection group with immunohistochemical stain scores of 2.275±1.511 and 1.588±1.698,respectively(P0.05).Conclusion Both H.pylori infection and aspirin participated in gastric mucosa injury are associated with proliferation of gastric epithelial cells in aspirin associated gastric mucosa injury diseases.