A comparative study of the application value of different doses of ambroxol in elderly patients with acute exacerbation of COPD

Objective To investigate the effects of different doses of ambroxol on lung function of patients with acute exacerbation of chronic obstructive pulmonary disease( AECOPD). Methods A hundred and two cases of AECOPD patients were randomly assigned into control group( n = 32),treated with bronchodilators,conventional oxygen and intravenous antibiotic therapy for 7 d,mucosolvan conventional-dose group( n = 35),treated with mucosolvan intravenous infusion therapy( 3 times /d) for 7 d,and mucosolvan high dose group( n = 35),treated with 150 mg /times mucosolvan( 2 times /d) for 7 d. The total effective rate,lung functions and blood indices of three groups before and after treatment were compared. Results Lung functions of all three groups were improved after treatment. The levels of FEV1. 0%,PEF% and FEV1. 0/FVC,6MWD of high-dose group were higher than the conventional dose group and the control group( P 0. 05). The levels of SaO2,PaO2,PaO2/FiO2 of high-dose group were higher than the conventional dose group and the control group after the treatment( P 0. 05). The total effective rates of high-dose group,conventional dose group and control group were94. 28%,82. 86% and 78. 13%,respectively( P 0. 05). There were 4 cases( 11. 43%),3 cases( 9. 37%),and 2 cases( 6. 25%)of adverse reactions in high-dose group,conventional dose group and control group,respectively. The adverse reaction rates were not statistically significant( P 0. 05). Conclusions High-dose ambroxol can effectively improve lung function and blood gas in patients with AECOPD,which achieves significant effects with less adverse reactions.