HIGH DOSE AMBROXOL IN TREATMENT OF CHILDREN WITH ACUTE LUNG INJURY

[Objective]With clinical practice experience,we explored the high dose ambroxol in treatment of children with clinical acute lung injury.[Methods]A control study,the children were randomly divided into 3 groups as control group(44 cases),the conventional dose group(44 cases)and high dose group(44 cases). The three different treatment methods were compared to explore the clinic effect of high dose ambroxol clinical in treatment of children with acute lung injury. We established a database using Microsoft Excel by using SPSS 13. 0 statistical software. All measurement data(mean ± standard deviation)were analyzed by using t test and χ2 test,taking P﹤0.05 for significant difference.[Results]Before treatment,PaO2 and PaO2/FiO2 among the three groups showed no significant difference. PaO2 and PaO2/FiO2 after treatment than before treatment was significantly improved after 3 d treatment,the PaO2 and PaO2/FiO2 of the high dose group was significantly higher than that of the conventional dose group,there was significant difference(P﹤0.05). The control group,the conventional dose group and high dose group were treated and those who progressed to ARDS patients were 10,8 and 2,respectively. There was significant difference between the two groups,and 6,5 and 1 patient died,respectively. The mortality rate in each group showed no significant difference between them. After excluding cases of ARDS,high-dose group recovered to 300 mm Hg PaO2/FiO2 over time was significantly shorter than that of the conventional dose group and control group(P﹤0.05),while the conventional dose group and the control group showed no significant difference between them(P﹥0.05).[Conclusion]Patients with ALI of ambroxol on lung function in children showed a protective effect of high dose ambroxol on pediatric ALI prevention,treatment and outcome has a good effect,and is worthy of clinical application.